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Publications

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1.     Knapp, C., Guo, P., and Whitehead, K. Lipidoid tail structure strongly influences siRNA delivery activity. Cellular and Molecular Bioengineering, 9:305, 2016.


2.     Knapp, C., He, J., Lister, J., and Whitehead, K. Lipidoid nanoparticle mediated silencing of Mcl-1 induces apoptosis in mantle cell lymphoma. Experimental Biology and Medicine, 241:1007-1013, 2016.


3.     Lamson, N., Cusimano, G., Suri, K., Zhang, A., and Whitehead, K. The pH of piperazine derivative solutions predicts their utility as transepithelial permeation enhancers. Molecular Pharmaceutics, (2):578-585, 2016.


4.     Kasiewicz, L. and Whitehead, K. Silencing TNF alpha with lipidoid nanoparticles downregulates both TNF alpha and MCP-1 in an in vitro co-culture model of diabetic foot ulcers. Acta Biomaterialia, (3):120-128, 2016.


5.     Ball, R., Knapp, C., and Whitehead, K. Lipidoid nanoparticles for siRNA delivery to the intestinal epithelium: in vitro investigations in a Caco-2 model. PLOS One, 10(7) ne.0133154, 2015.


6.     Veiseh, O., Tang, B., Whitehead, K., Langer, R., and Anderson, D. Managing diabetes with nanomedicine: Challenges and opportunities. Nature Reviews Drug Discovery, : 45-57, 2015.


7.     Knapp, C. and Whitehead, K. In pursuit of a moving target: Nanotherapeutics for the treatment of Non-Hodgkin B-cell lymphoma. Expert Opinion on Drug Delivery, (12): 1923-1937, 2014.




SCIENCE TRANSLATIONAL MEDICINE - ASSOCIATE SCIENTIFIC ADVISOR ARTICLES


1.     Whitehead, K. Protecting kids with a patch. Science Translational Medicine, 8: 361ec169, Oct. 19, 2016.


2.     Whitehead, K. Gobbling up inflammation to ameliorate autoimmunity. Science Translational Medicine, 8: 355ec145, Sept 7, 2016.


3.     Whitehead, K. A captive peptide for T cell activation. Science Translational Medicine, 8: 349ec121, July 27, 2016.


4.     Whitehead, K. Pancreatic cells play switcheroo. Science Translational Medicine, 8: 343ec97, June 15, 2016.


5.     Whitehead, K. A one-two punch for pain management. Science Translational Medicine, 8: 336ec69, April 27, 2016.


6.     Whitehead, K. A cage for pathogens. Science Translational Medicine, 8: 331ec49, March 23, 2016.



POSTDOC RESEARCH


8.     Whitehead, K., Dorkin, J., Vegas, A., Chang, P., Veiseh, O., Matthews, J., Fenton, O., Zhang, Y., Olejnik, K., Chen, D., Barros, S., Klebanov, B., Novobrantseva, T., Langer, R., and Anderson, D. Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity. Nature Communications, 5: 4277 doi:10.1038/ncomms5277, 2014.


9.     Mizrahi, B., Shankarappa, S., Hickey, J., Dohlman, J., Timko, B., Whitehead, K., Lee, J. J., Langer, R., Anderson, D., and Kohane, D. A stiff injectable biodegradable elastomer. Advanced Healthcare Materials, (12): 1527-33, 2013.


10.     Whitehead, K., Matthews, J., Chang, P., Dorkin, J. R., Niroui, F., Severgnini, M., Anderson, D. In vitro – in vivo translation of lipid nanoparticles for hepatocellular siRNA delivery. ACS Nano, (8): 6922-9, 2012.


11.     Chen, D., Love, K., Chen, Y., Eltoukhy, A., Kastrup, C., Sahay, G., Jeon, A., Dong, Y., Whitehead, K., Langer, R., and Anderson, D. Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation. JACS, (16): 6948-51, 2012.


12.     Kanasty, R., Whitehead, K., Vegas, A., Langer, R., and Anderson, D. Action and reaction: The biological response to siRNA and its delivery vehicles. Molecular Therapy, 513-24, 2012.


13.     Novobrantseva, T. I., Borodovsky, A., Wong, J., Klebanov, B., Zafari, M., Yucius, K., Querbes, W., Ge, P., Ruda, V., Milstein, S., Speciner, L., Duncan, R., Barros, S., Basha, G., Cullis, P., Akinc, A., Donahoe, J.S., Jayaprakash, N., Jayaraman, M., Bogorad, R.L., Love, K.T., Whitehead, K., Levins, C., Manoharan, M., Swirski, F.K., Weissleder, R., Langer, R., Anderson, D.G., de Fougerolles, A., Nahrendorf, M.,Koteliansky, V. Systemic RNAi-mediated gene silencing in non-human primate and rodent myeloid cells. Molecular Therapy Nucleic Acids, 1, e4; doi:10.1038/mtna.2011.3, 2012.


14.     Whitehead, K., Sahay, G., Li, G., Love, K., Alabi, C., Ma, M., Zurenko, C., Querbes, W., Langer, R., and Anderson, D. Synergistic silencing: Binary combinations of lipid-like materials for efficacious siRNA delivery. Molecular Therapy, (9):1688-94, 2011.


15.     Siegwart, D., Whitehead, K., Nuhn, L., Sahay, G., Cheng, H., Jiang, S., Ma, M., Lytton-Jean, A., Vegas, A., Fenton, P., Levins, C., Love, K., Lee, H., Cortez, C., Collins, S., Li, Y., Jang, J., Querbes, W., Zurenko, C., Novobrantseva, T., Langer, R., and Anderson, D. Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery. PNAS, :12996-13001, 2011.


16.     Whitehead, K., Dahlman, J., Langer, R., and Anderson, D. Silencing or stimulation? siRNA delivery and the immune system. Annual Review of Chemical and Biomolecular Engineering, :77-96, 2011.


17.     Timko, B., Whitehead, K., Gao, W., Kohane, D., Farokhzad, O., Anderson, D., and Langer, R. Advances in drug delivery. Annual Review of Materials Research, :1-20, 2011.


18.     Mahon, K., Love, K., Whitehead, K., Akinc, A., Leshchiner, E., Leshchiner, I., Langer, R., and Anderson, D. A combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery.  Bioconjugate Chemistry, (8):1448-54, 2010.  


19.     Love, K., Mahon, K., Levins, C., Whitehead, K., Querbes, W., Dorkin, R., Qin, J., Cantley, W., Qin, J., Racie, T., Frank-Kamesky, M., Yip, K. N., Alvarez, R., Sah, D., de Fougerolles, A., Fitzgerald, K., Kotelianski, V., Akinc, A., Langer, R., and Anderson, D. Lipid-like materials for low dose, in vivo gene silencing. PNAS, (5):1864-9, 2010.


20.     Cheng, H., Kastrup, C., Ramanathan, R., Siegwart, D., Ma, M., Bogatyrev, S., Xu, Q., Whitehead, K., Langer, R., Anderson, D. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. ACS Nano, (2):625-31, 2010.


21.     Whitehead, K., Langer, R., and Anderson, D. Knocking down barriers: Advances in siRNA delivery. Nature Reviews Drug Discovery, (2):129-38, 2009.  



PH.D. RESEARCH



22.     Whitehead, K. and Mitragotri, S. Mechanistic analysis of chemical permeation enhancers for oral drug delivery. Pharmaceutical Research, : 1412-9, 2008.


23.     Whitehead, K., Karr, N., and Mitragotri, S. Discovery of synergistic permeation enhancers for oral drug delivery. Journal of Controlled Release, 128-33, 2008.


24.     Whitehead, K., Karr, N., and Mitragotri, S. Safe and effective permeation enhancers for oral drug delivery. Pharmaceutical Research, : 1782-8, 2008.


25.     Whitehead, K. and Mitragotri, S. Oral delivery of macromolecules. Drug Delivery Companies Report, Pharmaventures. Spring/Summer 2005.


26.     Whitehead, K., Shen, Z., and Mitragotri, S. Oral delivery of macromolecules using intestinal patches: Applications for insulin delivery. Journal of Controlled Release, 37-45, 2004.